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1aoi
From Proteopedia
| 1aoi, resolution 2.80Å () | |||||||||
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| Ligands: | |||||||||
| Domains: | H2A, H4, H3, H2B | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.
Crystal structure of the nucleosome core particle at 2.8 A resolution., Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ, Nature. 1997 Sep 18;389(6648):251-60. PMID:9305837
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1AOI is a Protein complex structure of sequences from Xenopus laevis. Additional information on 1AOI is available in a page on Nucleosome at the RCSB PDB Molecule of the Month. Full crystallographic information is available from OCA.
Reference
Crystal structure of the nucleosome core particle at 2.8 A resolution., Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ, Nature. 1997 Sep 18;389(6648):251-60. PMID:9305837
Page seeded by OCA on Wed Jul 23 10:59:11 2008
