Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.,Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746
