Structural highlights
Function
RIB4_YEAST Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Garcia-Ramirez JJ, Santos MA, Revuelta JL. The Saccharomyces cerevisiae RIB4 gene codes for 6,7-dimethyl-8-ribityllumazine synthase involved in riboflavin biosynthesis. Molecular characterization of the gene and purification of the encoded protein. J Biol Chem. 1995 Oct 6;270(40):23801-7. PMID:7559556
- ↑ Mortl S, Fischer M, Richter G, Tack J, Weinkauf S, Bacher A. Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. J Biol Chem. 1996 Dec 27;271(52):33201-7. PMID:8969176