1gos

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1gos, resolution 3.00Å ()
Ligands: ,
Activity: Monoamine oxidase, with EC number 1.4.3.4
Related: 1h8r
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

HUMAN MONOAMINE OXIDASE B

Publication Abstract from PubMed

Monoamine oxidase B (MAO B) is a mitochondrial outermembrane flavoenzyme that is a well-known target for antidepressant and neuroprotective drugs. We determined the structure of the human enzyme to 3 A resolution. The enzyme binds to the membrane through a C-terminal transmembrane helix and apolar loops located at various positions in the sequence. The electron density shows that pargyline, an analog of the clinically used MAO B inhibitor, deprenyl, binds covalently to the flavin N5 atom. The active site of MAO B consists of a 420 A(3)-hydrophobic substrate cavity interconnected to an entrance cavity of 290 A(3). The recognition site for the substrate amino group is an aromatic cage formed by Tyr 398 and Tyr 435. The structure provides a framework for probing the catalytic mechanism, understanding the differences between the B- and A-monoamine oxidase isoforms and designing specific inhibitors.

Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders., Binda C, Newton-Vinson P, Hubalek F, Edmondson DE, Mattevi A, Nat Struct Biol. 2002 Jan;9(1):22-6. PMID:11753429

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1gos is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Binda C, Newton-Vinson P, Hubalek F, Edmondson DE, Mattevi A. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol. 2002 Jan;9(1):22-6. PMID:11753429 doi:10.1038/nsb732

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