1gxr

From Proteopedia

Jump to: navigation, search


1gxr, resolution 1.65Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



WD40 Region of Human Groucho/TLE1

Publication Abstract from PubMed

Groucho (Gro)/TLE proteins are transcriptional corepressors that lack inherent DNA binding but interact with DNA-bound transcription factors and histones, and recruit histone deacetylases. Groucho-mediated repression is essential in embryonic development and involved in regulation of Wnt signaling in adult tissue. We have determined the 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions. The structure confirms the relationship to the yeast Tup1 corepressor, but reveals important structural differences specific to the metazoan system. Analysis of missense mutations in the C. elegans Groucho homolog UNC-37 identifies sites of interaction with repression effectors, and suggests an induced fit binding site for eh1 domains of Engrailed-type transcription factors.

Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor., Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH, Structure. 2002 Jun;10(6):751-61. PMID:12057191

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1gxr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH. Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. Structure. 2002 Jun;10(6):751-61. PMID:12057191

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools