1iob

From Proteopedia

Jump to: navigation, search


1iob, resolution 2.00Å, 1 NMR models ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT

Publication Abstract from PubMed

Joint refinement of macromolecules against crystallographic and nuclear magnetic resonance (NMR) observations is presented as a way of combining experimental information from the two methods. The model of interleukin-1 beta derived by the joint x-ray and NMR refinement is shown to be consistent with the experimental observations of both methods and to have crystallographic R value and geometrical parameters that are of the same quality as or better than those of models obtained by conventional crystallographic studies. The few NMR observations that are violated by the model serve as an indicator for genuine differences between the crystal and solution structures. The joint x-ray-NMR refinement can resolve structural ambiguities encountered in studies of multidomain proteins, in which low- to medium-resolution diffraction data can be complemented by higher resolution NMR data obtained for the individual domains.

Combining experimental information from crystal and solution studies: joint X-ray and NMR refinement., Shaanan B, Gronenborn AM, Cohen GH, Gilliland GL, Veerapandian B, Davies DR, Clore GM, Science. 1992 Aug 14;257(5072):961-4. PMID:1502561

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1iob is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Shaanan B, Gronenborn AM, Cohen GH, Gilliland GL, Veerapandian B, Davies DR, Clore GM. Combining experimental information from crystal and solution studies: joint X-ray and NMR refinement. Science. 1992 Aug 14;257(5072):961-4. PMID:1502561

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools