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From Proteopedia

1jxv, resolution 2.20Å ()
Gene:	nm23-H1 (Homo sapiens)
Activity:	Nucleoside-diphosphate kinase, with EC number 2.7.4.6
Domains:	NDPk_I
Structural annotation: Resources: CATH : 1Jxva00, 1Jxvb00, 1Jxvc00, 1Jxvd00, 1Jxve00, 1Jxvf00 InterPro : Ipr012005, Ipr001564 Pfam : PF00334 SCOP : d1jxva_, d1jxvb_, d1jxvc_, d1jxvd_, d1jxve_, d1jxvf_ UniProt : P15531
Functional annotation: Resources: GeneCard : NME1 Cellular component: cytoplasm nucleus Biological process: CTP biosynthetic process GTP biosynthetic process UTP biosynthetic process nucleotide metabolic process negative regulation of cell proliferation cell cycle regulation of apoptosis pyrimidine ribonucleoside triphosphate biosynthetic process positive regulation of epithelial cell proliferation negative regulation of cell cycle nucleoside triphosphate biosynthetic process Molecular function: deoxyribonuclease activity magnesium ion binding nucleotide binding kinase activity nucleoside diphosphate kinase activity transferase activity DNA binding metal ion binding ATP binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Crystal Structure of Human Nucleoside Diphosphate Kinase A

About this Structure

1JXV is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW. Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor. Proteins. 2002 Feb 15;46(3):340-2. PMID:11835509

Page seeded by OCA on Tue Feb 17 21:00:53 2009