1ksq
From Proteopedia
NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1
Structural highlights
DiseaseLTBP1_HUMAN Autosomal recessive cutis laxa type 1. The disease is caused by variants affecting the gene represented in this entry. FunctionLTBP1_HUMAN Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).[1] [2] [3] [4] [5] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
| ||||||||||||||||||
Categories: Homo sapiens | Large Structures | Downing AK | Handford PA | Knott V | Lack J | O'leary JM | Rifkin DB | Yuan X
