1l3x

Structural highlights

Function

VM2HS_GLOBR Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).^{[1] [2] [3] [4] [5]} Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.^{[6] [7] [8] [9] [10]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Disintegrin

References

1. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
2. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
3. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
4. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
5. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354
6. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
7. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
8. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
9. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
10. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354