First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

1lfa

From Proteopedia

Jump to: navigation, search


1lfa, resolution 1.80Å ()
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

CD11A I-DOMAIN WITH BOUND MN++

Publication Abstract from PubMed

We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin., Qu A, Leahy DJ, Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:7479767

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1lfa is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Qu A, Leahy DJ. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:7479767

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools