1nvm

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Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate

Structural highlights

1nvm is a 8 chain structure with sequence from Pseudomonas sp. CF600. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:MN, MPD, NAD, OXL, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HOA_PSEUF Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds such as phenols, cresols and catechols.[HAMAP-Rule:MF_01656][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Shingler V, Powlowski J, Marklund U. Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600. J Bacteriol. 1992 Feb;174(3):711-24. PMID:1732207

Contents


PDB ID 1nvm

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