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|1oia, resolution 2.40Å ()|
|Related:||1aud, 1cx0, 1drz, 1dz5, 1fht, 1m5k, 1m5o, 1m5p, 1m5v, 1nu4, 1urn, 2u1a, 3utr|
U1A RNP DOMAIN 1-95
The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A., Nagai K, Oubridge C, Jessen TH, Li J, Evans PR, Nature. 1990 Dec 6;348(6301):515-20. PMID:2147232
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.