# 1psl

### From Proteopedia

Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |

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1psl ()
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Resources:
| FirstGlance, PDBsum | |

Coordinates:
| save as pdb, mmCIF, xml |

### COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN

Structural and environmental constraints greatly simplify the folding problem for membrane proteins. Computational methods can be used in a global search to find a small number of chemically reasonable models within these constraints, such that a modest set of experimental data can distinguish among them. We show that, for phospholamban, the global search can be further simplified by reducing the problem to two-body, rather than many-body, interactions. This method of a constrained global search combined with experimental mutagenesis data yields a three-dimensional structure for this pentameric ion channel. The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues.

*Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban., Adams PD, Arkin IT, Engelman DM, Brunger AT, Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

## Reference

- Adams PD, Arkin IT, Engelman DM, Brunger AT. Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban. Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920