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1r54
From Proteopedia
| 1r54, resolution 1.85Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||||
| Non-Standard Residues: | |||||||||
| Gene: | ADAM33 (Homo sapiens) | ||||||||
| Domains: | ZnMc_adamalysin_II_like | ||||||||
| Related: | 1r55 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of the catalytic domain of human ADAM33
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1R54 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V. Crystal structure of the catalytic domain of human ADAM33. J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
Page seeded by OCA on Mon Feb 16 15:22:36 2009
Categories: Homo sapiens | Hammond, G. | Mirza, U A. | Orth, P. | Prosise, W W. | Reicher, P. | Strickland, C. | Taremi, S S. | Wang, W. | Xiao, L. | Yarosh-Tomaine, T. | Zou, J. | Adam | Asthma | Metalloprotease
