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1tgh
From Proteopedia
| 1tgh, resolution 2.90Å () | |
|---|---|
| Gene: | TBP (Homo sapiens) |
| Domains: | TBP_eukaryotes, SPT15 |
| Resources: | FirstGlance, OCA, PDBsum, RCSB |
| Coordinates: | save as pdb, mmCIF, xml |
Contents |
TATA BINDING PROTEIN (TBP)/DNA COMPLEX
The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1TGH is a Single protein structure of sequence from Homo sapiens. Additional information on 1TGH is available in a page on TATA-Binding Protein at the RCSB PDB Molecule of the Month. Full crystallographic information is available from OCA.
Reference
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
Page seeded by OCA on Wed Jul 23 10:51:25 2008
