Structural highlights
Function
ZFAN5_MOUSE Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Hishiya A, Ikeda K, Watanabe K. A RANKL-inducible gene Znf216 in osteoclast differentiation. J Recept Signal Transduct Res. 2005;25(3):199-216. PMID:16194934 doi:http://dx.doi.org/10.1080/10799890500240781
- ↑ Hishiya A, Iemura S, Natsume T, Takayama S, Ikeda K, Watanabe K. A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy. EMBO J. 2006 Feb 8;25(3):554-64. Epub 2006 Jan 19. PMID:16424905 doi:http://dx.doi.org/10.1038/sj.emboj.7600945
