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1yl4

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1yl4, resolution 5.50Å ()
Related: 1yl3, 1jgo, 1j5e
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal structure of 70S ribosome with thrS operator and tRNAs. 30S subunit. The coordinates for the 50S subunit are in the pdb entry 1YL3

Publication Abstract from PubMed

The ribosome of Thermus thermophilus was cocrystallized with initiator transfer RNA (tRNA) and a structured messenger RNA (mRNA) carrying a translational operator. The path of the mRNA was defined at 5.5 angstroms resolution by comparing it with either the crystal structure of the same ribosomal complex lacking mRNA or with an unstructured mRNA. A precise ribosomal environment positions the operator stem-loop structure perpendicular to the surface of the ribosome on the platform of the 30S subunit. The binding of the operator and of the initiator tRNA occurs on the ribosome with an unoccupied tRNA exit site, which is expected for an initiation complex. The positioning of the regulatory domain of the operator relative to the ribosome elucidates the molecular mechanism by which the bound repressor switches off translation. Our data suggest a general way in which mRNA control elements must be placed on the ribosome to perform their regulatory task.

Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding., Jenner L, Romby P, Rees B, Schulze-Briese C, Springer M, Ehresmann C, Ehresmann B, Moras D, Yusupova G, Yusupov M, Science. 2005 Apr 1;308(5718):120-3. PMID:15802605

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1yl4 is a 24 chain structure with sequence from Thermus thermophilus and Thermus thermophilus hb8. Full crystallographic information is available from OCA.

See Also

Reference

  • Jenner L, Romby P, Rees B, Schulze-Briese C, Springer M, Ehresmann C, Ehresmann B, Moras D, Yusupova G, Yusupov M. Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding. Science. 2005 Apr 1;308(5718):120-3. PMID:15802605 doi:308/5718/120

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