|1yrk, resolution 1.70Å ()|
The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain
In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
- Sondermann H, Kuriyan J. C2 can do it, too. Cell. 2005 Apr 22;121(2):158-60. PMID:15851022 doi:http://dx.doi.org/10.1016/j.cell.2005.04.001
- Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 2005 Apr 22;121(2):271-80. PMID:15851033 doi:S0092-8674(05)00164-9