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From Proteopedia

2cue, 20 NMR models ()
Gene:	PAX6 (Homo sapiens)
Domains:	homeodomain
Structural annotation: Resources: InterPro : Ipr009057, Ipr012287, Ipr001523, Ipr001356, Ipr011991 Pfam : PF00046 UniProt : P26367
Functional annotation: Resources: GeneCard : PAX6 Cellular component: nucleus Biological process: regulation of transcription, DNA-dependent transcription organ morphogenesis eye development central nervous system development multicellular organismal development regulation of transcription cell differentiation visual perception Molecular function: sequence-specific DNA binding transcription factor activity DNA binding protein binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates:	save as pdb, mmCIF, xml

Solution structure of the homeobox domain of the human paired box protein Pax-6

Disease

Known disease associated with this structure: Aniridia OMIM:[607108], Cataract with late-onset corneal dystrophy OMIM:[607108], Coloboma of optic nerve OMIM:[607108], Coloboma, ocular OMIM:[607108], Ectopia pupillae OMIM:[607108], Foveal hyperplasia OMIM:[607108], Gillespie synd OMIM:[607108], Keratitis OMIM:[607108], Morning glory disc anomaly OMIM:[607108], Optic nerve hypoplasia OMIM:[607108], Peters anomaly OMIM:[607108]

About this Structure

2CUE is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Page seeded by OCA on Wed Feb 18 00:13:05 2009