2dt9

Structural highlights

Function

AK_THETH Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Nishiyama M, Kukimoto M, Beppu T, Horinouchi S. An operon encoding aspartokinase and purine phosphoribosyltransferase in Thermus flavus. Microbiology. 1995 May;141 ( Pt 5):1211-9. PMID:7773416
2. ↑ Kobashi N, Nishiyama M, Tanokura M. Kinetic and mutation analyses of aspartate kinase from Thermus flavus. J Biosci Bioeng. 1999;87(6):739-45. PMID:16232547