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From Proteopedia

2gsf, resolution 1.77Å ()
Gene:	EPHA3, ETK, ETK1, HEK (Homo sapiens)
Activity:	Receptor protein-tyrosine kinase, with EC number 2.7.10.1
Structural annotation: Resources: InterPro : Ipr001426, Ipr000719, Ipr003962, Ipr011009, Ipr003961, Ipr010993, Ipr008979, Ipr008266, Ipr001090, Ipr011510, Ipr001660, Ipr001245, Ipr008957, Ipr013761, Ipr013032 Pfam : PF07647, PF07714 UniProt : Q6P4R6
Functional annotation: Cellular component: membrane integral to membrane Biological process: protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway Molecular function: protein kinase activity kinase activity receptor activity nucleotide binding ATP binding transferase activity protein-tyrosine kinase activity ephrin receptor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region

Disease

[EPHA3_HUMAN] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].

Function

[EPHA3_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.^[1]

About this Structure

2gsf is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Ephrin receptor

Reference

1. ↑ Lawrenson ID, Wimmer-Kleikamp SH, Lock P, Schoenwaelder SM, Down M, Boyd AW, Alewood PF, Lackmann M. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J Cell Sci. 2002 Mar 1;115(Pt 5):1059-72. PMID:11870224