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2j00
From Proteopedia
| 2j00, resolution 2.80Å () | |||||||||
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| Ligands: | , , | ||||||||
| Non-Standard Residues: | |||||||||
| Related: | 2j01, 2j02, 2j03, 1fjg, 1gix, 1i94, 1i95, 1i96, 1i97, 1ibk, 1ibl, 1ibm, 1j5e, 1jgo, 1jgp, 1jgq, 1l1u, 1n32, 1n33, 1n34, 1n36, 1pns, 1pnx, 1xmo, 1xmq, 1xnq, 1xnr, 1yl4, 2b64, 2b9m, 2b9o, 2f4v | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 1 OF 4). THIS FILE CONTAINS THE 30S SUBUNIT, MRNA, A-, P- AND E-SITE TRNAS AND PAROMOMYCIN FOR MOLECULE I.
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation.
Structure of the 70S ribosome complexed with mRNA and tRNA., Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V, Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2j00 is a 25 chain structure with sequence from Escherichia coli and Thermus thermophilus. Full crystallographic information is available from OCA.
See Also
- Ribosomal protein S10
- Ribosomal protein S11
- Ribosomal protein S12
- Ribosomal protein S13
- Ribosomal protein S14
- Ribosomal protein S15
- Ribosomal protein S16
- Ribosomal protein S17
- Ribosomal protein S18
- Ribosomal protein S19
- Ribosomal protein S2
- Ribosomal protein S20
- Ribosomal protein S3
- Ribosomal protein S4
- Ribosomal protein S5
- Ribosomal protein S6
- Ribosomal protein S7
- Ribosomal protein S8
- Ribosomal protein S9
- Ribosomal protein THX
- Ribosome
Reference
- Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V. Structure of the 70S ribosome complexed with mRNA and tRNA. Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973
- Hedrick EG, Hill WE. Protein S20 binds two 16S rRNA sites as assembly is initiated. J Mol Biol. 2010 Aug 20;401(3):493-502. Epub 2010 Jun 30. PMID:20600110 doi:10.1016/j.jmb.2010.06.047
