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2jjt
From Proteopedia
| 2jjt, resolution 2.30Å () | |||||||||
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| Sites: | , , , , and | ||||||||
| Ligands: | |||||||||
| Non-Standard Residues: | |||||||||
| Domains: | IGv, V-set | ||||||||
| Related: | 2jjs, 2vsc, 2uv3 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
STRUCTURE OF HUMAN CD47 IN COMPLEX WITH HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA
CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells. We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresponding regions in SIRPalpha. We have also determined structures of the N-terminal domains of SIRPbeta, SIRPbeta(2), and SIRPgamma; proteins that are closely related to SIRPalpha but bind CD47 with negligible or reduced affinity. These results explain the specificity of CD47 for the SIRP family of paired receptors in atomic detail. Analysis of SIRPalpha polymorphisms suggests that these, as well as the activating SIRPs, may have evolved to counteract pathogen binding to the inhibitory SIRPalpha receptor.
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47., Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN, Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2JJT is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:S1097-2765(08)00434-6
Page seeded by OCA on Mon Feb 16 19:48:40 2009
Categories: Homo sapiens | Barclay, A N. | Graham, S C. | Harlos, K. | Hatherley, D. | Stuart, D I. | Turner, J. | Alternative splicing | Cd47 | Cell adhesion | Glycoprotein | Immunoglobulin domain | Immunoglobulin superfamily | Membrane | Paired receptor | Phosphoprotein | Polymorphism | Pyrrolidone carboxylic acid | Sh3-binding | Signal regulatory protein alpha | Sirp | Sirpa | Transmembrane
