2kpy

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Solution Structure of the major allergen of Artemisia vulgaris (Art v 1)

Structural highlights

2kpy is a 1 chain structure with sequence from Artemisia vulgaris. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALL1_ARTVU

Publication Abstract from PubMed

The interaction of specific IgE antibodies with allergens is a key event in the induction of allergic symptoms, thus representing an important target for therapeutic interventions in Type I allergies. We report here the solution NMR structure of Art v 1, the major mugwort pollen allergen. Art v 1 is the first protein structure with an allergenic defensin fold linked to a polyproline domain, which has not been identified in any reported allergen structure in the PDB. Moreover, the direct interaction of polyclonal IgE antibodies from an allergic patient has been mapped on the surface of an allergen for the first time. The data presented herein provide the basis for the design of tools for safe and effective vaccination against mugwort pollen allergy.

Mapping the interactions between a major pollen allergen and human IgE antibodies.,Razzera G, Gadermaier G, de Paula V, Almeida MS, Egger M, Jahn-Schmid B, Almeida FC, Ferreira F, Valente AP Structure. 2010 Aug 11;18(8):1011-21. PMID:20696401[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
10 reviews cite this structure
Allergens of weed pollen: an overview on recombinant and natural molecules.
Gadermaier et al. (2014)
9 more
21 other articles
No citations found

References

  1. ↑ Razzera G, Gadermaier G, de Paula V, Almeida MS, Egger M, Jahn-Schmid B, Almeida FC, Ferreira F, Valente AP. Mapping the interactions between a major pollen allergen and human IgE antibodies. Structure. 2010 Aug 11;18(8):1011-21. PMID:20696401 doi:10.1016/j.str.2010.05.012

Contents


PDB ID 2kpy

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OCA

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