2l0b

Structural highlights

Function

[PJA1_HUMAN] Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Ubiquitin protein ligase 3D structures

References

1. ↑ Yu P, Chen Y, Tagle DA, Cai T. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Genomics. 2002 Jun;79(6):869-74. PMID:12036302 doi:http://dx.doi.org/10.1006/geno.2002.6770