Structural highlights
Function
MIEN1_HUMAN Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.[1] [2]
References
- ↑ Dasgupta S, Wasson LM, Rauniyar N, Prokai L, Borejdo J, Vishwanatha JK. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. Oncogene. 2009 Aug 13;28(32):2860-72. doi: 10.1038/onc.2009.145. Epub 2009 Jun 8. PMID:19503095 doi:http://dx.doi.org/10.1038/onc.2009.145
- ↑ Dasgupta S, Cushman I, Kpetemey M, Casey PJ, Vishwanatha JK. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem. 2011 Jul 22;286(29):25935-46. doi: 10.1074/jbc.M111.254599. Epub, 2011 May 31. PMID:21628459 doi:http://dx.doi.org/10.1074/jbc.M111.254599