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2p03

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2p03, 1 NMR models ()
Gene: LRPAP1 (Homo sapiens)
Related: 2p01
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

The structure of receptor-associated protein(RAP)

Publication Abstract from PubMed

The receptor-associated protein (RAP) is a molecular chaperone that binds tightly to certain newly synthesized LDL receptor family members in the endoplasmic reticulum (ER) and facilitates their delivery to the Golgi. We have adopted a divide-and-conquer strategy to solve the structures of the individual domains of RAP using NMR spectroscopy. We present here the newly determined structure of domain 2. Based on this structure and the structures of domains 1 and 3, which were solved previously, we utilized experimental small-angle neutron scattering (SANS) data and a novel simulated annealing protocol to characterize the overall structure of RAP. The results reveal that RAP adopts a unique structural architecture consisting of three independent three-helix bundles that are connected by long and flexible linkers. The flexible linkers and the quasi-repetitive structural architecture may allow RAP to adopt various possible conformations when interacting with the LDL receptors, which are also made of repetitive substructure units.

The structure of receptor-associated protein (RAP)., Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DK, Wang YX, Protein Sci. 2007 Aug;16(8):1628-40. PMID:17656581

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Disease

[AMRP_HUMAN] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.

Function

[AMRP_HUMAN] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

About this Structure

2p03 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DK, Wang YX. The structure of receptor-associated protein (RAP). Protein Sci. 2007 Aug;16(8):1628-40. PMID:17656581 doi:16/8/1628

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