Structural highlights
Function
MURI_ENTFA Provides the (R)-glutamate required for cell wall biosynthesis.[HAMAP-Rule:MF_00258]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.,Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B. Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367 doi:http://dx.doi.org/10.1016/j.bmcl.2008.06.068
