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2wh2
From Proteopedia
Contents |
INSIGHTS INTO TRANSLATIONAL TERMINATION FROM THE STRUCTURE OF RF2 BOUND TO THE RIBOSOME
The termination of protein synthesis occurs through the specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of the nascent protein chain from the P-site transfer RNA. Here we present, at a resolution of 3.5 angstroms, the crystal structure of RF2 in complex with its cognate UGA stop codon in the 70S ribosome. The structure provides insight into how RF2 specifically recognizes the stop codon; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of peptide release.
Insights into translational termination from the structure of RF2 bound to the ribosome., Weixlbaumer A, Jin H, Neubauer C, Voorhees RM, Petry S, Kelley AC, Ramakrishnan V, Science. 2008 Nov 7;322(5903):953-6. PMID:18988853
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2wh2 is a 33 chain structure with sequence from Thermus thermophilus. This structure supersedes the now removed PDB entry 2jl6. Full crystallographic information is available from OCA.
See Also
- Kink-turn motif
- Ribosomal protein L1
- Ribosomal protein L10
- Ribosomal protein L11
- Ribosomal protein L13
- Ribosomal protein L14
- Ribosomal protein L15
- Ribosomal protein L16
- Ribosomal protein L17
- Ribosomal protein L18
- Ribosomal protein L19
- Ribosomal protein L2
- Ribosomal protein L20
- Ribosomal protein L21
- Ribosomal protein L22
- Ribosomal protein L23
- Ribosomal protein L24
- Ribosomal protein L25
- Ribosomal protein L27
- Ribosomal protein L28
- Ribosomal protein L29
- Ribosomal protein L3
- Ribosomal protein L30
- Ribosomal protein L31
- Ribosomal protein L32
- Ribosomal protein L33
- Ribosomal protein L34
- Ribosomal protein L35
- Ribosomal protein L36
- Ribosomal protein L4
- Ribosomal protein L5
- Ribosomal protein L6
- Ribosomal protein L9
- User:Wayne Decatur/kink-turn motif
Reference
- Weixlbaumer A, Jin H, Neubauer C, Voorhees RM, Petry S, Kelley AC, Ramakrishnan V. Insights into translational termination from the structure of RF2 bound to the ribosome. Science. 2008 Nov 7;322(5903):953-6. PMID:18988853 doi:322/5903/953
Categories: Thermus thermophilus | Jin, H. | Kelley, A C. | Neubauer, C. | Petry, S. | Ramakrishnan, V. | Voorhees, R M. | Weixlbaumer, A. | Mrna | Rf2 | Ribosome | Termination | Translation | Trna
