First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

2yjd

From Proteopedia

Jump to: navigation, search


2yjd, resolution 1.93Å ()
Sites: and
Ligands:
Non-Standard Residues: , ,
Related: 2yly, 1l2j, 2fsz, 1x7b, 1x76, 1nde, 2jj3, 1yy4, 1u3s, 1x78, 1qkm, 1u3r, 1x7j, 1u9e, 1yye, 1u3q, 2yja, 2ldd, 2lda, 2ldc


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA

Publication Abstract from PubMed

Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor-stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general.

Design and structure of stapled peptides binding to estrogen receptors., Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL, J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2yjd is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL. Design and structure of stapled peptides binding to estrogen receptors. J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236 doi:10.1021/ja202946k

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools