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2yly

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2yly, resolution 3.20Å ()
Ligands: ,
Related: 1yy4, 1u3s, 1x78, 1qkm, 1u3r, 1l2j, 2fsz, 1x7j, 1x7b, 1u9e, 1x76, 1nde, 1yye, 2jj3, 1u3q


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Sulfonamides as selective Estrogen Receptor beta Agonists.

Publication Abstract from PubMed

A series of p-hydroxybenzenesulphonamides ERbeta receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERalpha receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERbeta agonists.

Sulfonamides as selective oestrogen receptor beta agonists., Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M, Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2yly is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M. Sulfonamides as selective oestrogen receptor beta agonists. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279 doi:10.1016/j.bmcl.2011.08.041

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