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Structural highlights

Function

AZIN1_MOUSE Inhibits antizyme-dependent ODC degradation by binding to antizyme with greater affinity. Regulates cellular polyamine homeostasis.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Antizyme Inhibitor
• Antizyme inhibitor 3D structures
• Ornithine decarboxylase

References

1. ↑ Nilsson J, Grahn B, Heby O. Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000 Mar 15;346 Pt 3:699-704. PMID:10698696
2. ↑ Albeck S, Dym O, Unger T, Snapir Z, Bercovich Z, Kahana C. Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function. Protein Sci. 2008 May;17(5):793-802. Epub 2008 Mar 27. PMID:18369191 doi:10.1110/ps.073427208