3cp2

Structural highlights

Function

MNMG_ECOLI NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Bregeon D, Colot V, Radman M, Taddei F. Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift. Genes Dev. 2001 Sep 1;15(17):2295-306. PMID:11544186 doi:http://dx.doi.org/10.1101/gad.207701
2. ↑ Yim L, Moukadiri I, Bjork GR, Armengod ME. Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. Nucleic Acids Res. 2006;34(20):5892-905. Epub 2006 Oct 24. PMID:17062623 doi:http://dx.doi.org/gkl752
3. ↑ Nakayashiki T, Inokuchi H. Novel temperature-sensitive mutants of Escherichia coli that are unable to grow in the absence of wild-type tRNA6Leu. J Bacteriol. 1998 Jun;180(11):2931-5. PMID:9603884