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|3e6y, resolution 2.50Å ()|
Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A
Cotylenin A, a fungal metabolite originally described as a cytokinin-like bioactive substance against plants shows differentiation-inducing and anti-tumor activity in certain human cancers. Here, we present the crystal structure of cotylenin A acting on a 14-3-3 regulatory protein complex. By comparison with the closely related, but non-anticancer agent fusicoccin A, a rationale for the activity of cotylenin A in human cancers is presented. This class of fusicoccane diterpenoids are possible general modulators of 14-3-3 protein-protein interactions. In this regard, specificities for individual 14-3-3/target protein complexes might be achieved by varying the substituent pattern of the diterpene ring system. As the different activities of fusicoccin A and cotylenin A in human cancers suggest, hydroxylation of C12 might be a sufficient determinant of structural specificity.
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A., Ottmann C, Weyand M, Sassa T, Inoue T, Kato N, Wittinghofer A, Oecking C, J Mol Biol. 2009 Mar 6;386(4):913-9. PMID:19244612
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
- Ottmann C, Weyand M, Sassa T, Inoue T, Kato N, Wittinghofer A, Oecking C. A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A. J Mol Biol. 2009 Mar 6;386(4):913-9. PMID:19244612