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3iin

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3iin, resolution 4.18Å ()
Ligands: ,
Non-Standard Residues: ,
Gene: SNRPA (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

Plasticity of the kink turn structural motif

Publication Abstract from PubMed

The kink turn (K-turn) is an RNA structural motif found in many biologically significant RNAs. While most examples of the K-turn have a similar fold, the crystal structure of the Azoarcus group I intron revealed a novel RNA conformation, a reverse kink turn bent in the direction opposite that of a consensus K-turn. The reverse K-turn is bent toward the major grooves rather than the minor grooves of the flanking helices, yet the sequence differs from the K-turn consensus by only a single nucleotide. Here we demonstrate that the reverse bend direction is not solely defined by internal sequence elements, but is instead affected by structural elements external to the K-turn. It bends toward the major groove under the direction of a tetraloop-tetraloop receptor. The ability of one sequence to form two distinct structures demonstrates the inherent plasticity of the K-turn sequence. Such plasticity suggests that the K-turn is not a primary element in RNA folding, but instead is shaped by other structural elements within the RNA or ribonucleoprotein assembly.

Plasticity of the RNA kink turn structural motif., Antonioli AH, Cochrane JC, Lipchock SV, Strobel SA, RNA. 2010 Apr;16(4):762-8. Epub 2010 Feb 9. PMID:20145044

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3iin is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Antonioli AH, Cochrane JC, Lipchock SV, Strobel SA. Plasticity of the RNA kink turn structural motif. RNA. 2010 Apr;16(4):762-8. Epub 2010 Feb 9. PMID:20145044 doi:10.1261/rna.1883810

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