Several atomic structures are now available for the family of helical cytokines, which includes growth hormone as well as many of the interleukins. Using structural information from five members of this family, two alternative models of interleukin (IL)-13 are proposed. IL-13 has biological properties similar to those of IL-4 and, like the other interleukins, is a potentially important pharmaceutical target. The model of IL-13 is discussed and compared with the known interleukin structures.
Predictive modelling of the 3-D structure of interleukin-13.,Bamborough P, Duncan D, Richards WG Protein Eng. 1994 Sep;7(9):1077-82. PMID:7530359
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Bamborough P, Duncan D, Richards WG. Predictive modelling of the 3-D structure of interleukin-13. Protein Eng. 1994 Sep;7(9):1077-82. PMID:7530359