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Crystal structure of the human cyclin G associated kinase (GAK)
[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
About this Structure
3ll6 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
- ↑ Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Arrowsmith, C H. | Bountra, C. | Delft, F Von. | Edwards, A. | Eswaran, J. | Fedorov, O. | Hatzos-Skintges, C. | Joachimiak, A. | King, O. | Knapp, S. | MCSG, Midwest Center for Structural Genomics. | SGC, Structural Genomics Consortium. | Weger, A. | Weigelt, J. | Zhang, R. | Atp-binding | Cell cycle | Cell junction | Clathrine | Cyclin g | Golgi apparatus | Kinase | Mcsg | Membrane trafficking | Midwest center for structural genomic | Nucleotide-binding | P53 | Phosphoprotein | Protein kinase | Protein structure initiative | Psi-2 | Serine/threonine kinase | Serine/threonine-protein kinase | Sgc | Structural genomic | Structural genomics consortium | Transferase