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4o38, resolution 2.10Å ()
Ligands: ,
Non-Standard Residues:
Activity: Non-specific serine/threonine protein kinase, with EC number
Related: 4c57, 4c58, 4c59

Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Crystal structure of the human cyclin G associated kinase (GAK)


[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]

About this Structure

4o38 is a 2 chain structure. This structure supersedes the now removed PDB entry 3ll6. Full crystallographic information is available from OCA.


  1. Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686

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