The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 A crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.
Structural basis of cooperative ligand binding by the glycine riboswitch.,Butler EB, Xiong Y, Wang J, Strobel SA Chem Biol. 2011 Mar 25;18(3):293-8. PMID:21439473
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