First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
|3pls, resolution 2.24Å ()|
|Gene:||MST1R, PTK8, RON (Homo sapiens)|
RON in complex with ligand AMP-PNP
A complex of RON(M1254T) with AMP-PNP and Mg(2+) reveals a substratelike positioning of Tyr1238 as well as likely catalysis-competent placement of the AMP-PNP and Mg(2+) components and indicates a tendency for cis phosphorylation. The structure shows how the oncogenic mutation may cause the constitutive activation and suggests a mechanistic hypothesis for the autophosphorylation of receptor tyrosine kinases.
The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis., Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP, Biochemistry. 2010 Sep 21;49(37):7972-4. PMID:20726546
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.