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3pls

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3pls, resolution 2.24Å ()
Sites: and
Ligands: ,
Gene: MST1R, PTK8, RON (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



RON in complex with ligand AMP-PNP

Publication Abstract from PubMed

A complex of RON(M1254T) with AMP-PNP and Mg(2+) reveals a substratelike positioning of Tyr1238 as well as likely catalysis-competent placement of the AMP-PNP and Mg(2+) components and indicates a tendency for cis phosphorylation. The structure shows how the oncogenic mutation may cause the constitutive activation and suggests a mechanistic hypothesis for the autophosphorylation of receptor tyrosine kinases.

The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis., Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP, Biochemistry. 2010 Sep 21;49(37):7972-4. PMID:20726546

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3pls is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP. The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. Biochemistry. 2010 Sep 21;49(37):7972-4. PMID:20726546 doi:10.1021/bi100409w

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