3px3

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Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N

Structural highlights

3px3 is a 2 chain structure with sequence from Streptomyces fradiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:EDO, SAH, T3Q
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYLM1_STRFR S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.[1] [2] [3]

References

  1. ↑ Gandecha AR, Large SL, Cundliffe E. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. Gene. 1997 Jan 15;184(2):197-203. PMID:9031628
  2. ↑ Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW. Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine. Biochemistry. 2002 Jul 23;41(29):9165-83. PMID:12119032
  3. ↑ Carney AE, Holden HM. Molecular Architecture of TylM1 from Streptomyces fradiae: an N,N-Dimethyltransferase Involved in the Production of dTDP-D-Mycaminose. Biochemistry. 2010 Dec 13. PMID:21142177 doi:10.1021/bi101733y

Contents


PDB ID 3px3

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OCA

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