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3ro2

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3ro2, resolution 2.30Å ()
Sites: , and
Ligands:
Gene: Gpsm2, Lgn, Pins (Mus musculus)
Related: 3ro3


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structures of the LGN/NuMA complex

Publication Abstract from PubMed

Asymmetric cell division requires the establishment of cortical cell polarity and the orientation of the mitotic spindle along the axis of cell polarity. Evidence from invertebrates demonstrates that the Par3/Par6/aPKC and NuMA/LGN/Galphai complexes, which are thought to be physically linked by the adaptor protein mInscuteable (mInsc), play indispensable roles in this process. However, the molecular basis for the binding of LGN to NuMA and mInsc is poorly understood. The high-resolution structures of the LGN/NuMA and LGN/mInsc complexes presented here provide mechanistic insights into the distinct and highly specific interactions of the LGN TPRs with mInsc and NuMA. Structural comparisons, together with biochemical and cell biology studies, demonstrate that the interactions of NuMA and mInsc with LGN are mutually exclusive, with mInsc binding preferentially. Our results suggest that the Par3/mInsc/LGN and NuMA/LGN/Galphai complexes play sequential and partially overlapping roles in asymmetric cell division.

LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Galphai/LGN/NuMA pathways., Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M, Mol Cell. 2011 Aug 5;43(3):418-31. PMID:21816348

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3ro2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Galphai/LGN/NuMA pathways. Mol Cell. 2011 Aug 5;43(3):418-31. PMID:21816348 doi:10.1016/j.molcel.2011.07.011

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