Structural highlights
3v0w is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| NonStd Res: | , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Escherichia coli infections, a leading cause of septic shock, remain a major threat to human health because of the fatal action to endotoxin (LPS). Therapeutic attempts to neutralize endotoxin currently focus on inhibiting the interaction of the toxic component lipid A with myeloid differentiating factor 2, which forms a trimeric complex together with Toll-like receptor 4 to induce immune cell activation. The 1.73-A resolution structure of the unique endotoxin-neutralizing protective antibody WN1 222-5 in complex with the core region shows that it recognizes LPS of all E. coli serovars in a manner similar to Toll-like receptor 4, revealing that protection can be achieved by targeting the inner core of LPS and that recognition of lipid A is not required. Such interference with Toll-like receptor complex formation opens new paths for antibody sepsis therapy independent of lipid A antagonists.
Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.,Gomery K, Muller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi:, 10.1073/pnas.1209253109. Epub 2012 Nov 26. PMID:23184990[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Gomery K, Muller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV. Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi:, 10.1073/pnas.1209253109. Epub 2012 Nov 26. PMID:23184990 doi:http://dx.doi.org/10.1073/pnas.1209253109
