Structural highlights
Function
DYR_SCHMA Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[1]
See Also
References
- ↑ Serrao VHB, Romanello L, Cassago A, de Souza JRT, Cheleski J, DeMarco R, Brandao-Neto J, Pereira HD. Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase. Acta Trop. 2017 Jun;170:190-196. doi: 10.1016/j.actatropica.2017.03.007. Epub, 2017 Mar 11. PMID:28288799 doi:http://dx.doi.org/10.1016/j.actatropica.2017.03.007