3wi3

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Crystal Structure of the Sld3/Treslin domain from yeast Sld3

Structural highlights

3wi3 is a 3 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:EDO, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SLD3_YEAST Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.[1] [2] [3]

References

  1. ↑ Kamimura Y, Tak YS, Sugino A, Araki H. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J. 2001 Apr 17;20(8):2097-107. PMID:11296242 doi:http://dx.doi.org/10.1093/emboj/20.8.2097
  2. ↑ Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev. 2003 May 1;17(9):1153-65. PMID:12730134 doi:http://dx.doi.org/10.1101/gad.1065903
  3. ↑ Tanaka T, Umemori T, Endo S, Muramatsu S, Kanemaki M, Kamimura Y, Obuse C, Araki H. Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J. 2011 May 18;30(10):2019-30. doi: 10.1038/emboj.2011.115. Epub 2011 Apr, 12. PMID:21487389 doi:http://dx.doi.org/10.1038/emboj.2011.115

Contents


PDB ID 3wi3

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