Structural highlights
Function
CHKA_HUMAN Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.[1]
Publication Abstract from PubMed
Applying a CHOK hold: Combined experimental and computational studies of the binding mode of a rationally designed inhibitor of the dimeric choline kinase alpha1 (CHOKalpha1) explain the molecular mechanism of negative cooperativity and how the monomers are connected. The results give insight into how the symmetry of the dimer can be partially conserved despite a lack of conservation in the static crystal structures.
The Mechanism of Allosteric Coupling in Choline Kinase alpha1 Revealed by the Action of a Rationally Designed Inhibitor.,Sahun-Roncero M, Rubio-Ruiz B, Saladino G, Conejo-Garcia A, Espinosa A, Velazquez-Campoy A, Gervasio FL, Entrena A, Hurtado-Guerrero R Angew Chem Int Ed Engl. 2013 Feb 25. doi: 10.1002/anie.201209660. PMID:23441033[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS One. 2009 Nov 12;4(11):e7819. doi: 10.1371/journal.pone.0007819. PMID:19915674 doi:10.1371/journal.pone.0007819
- ↑ Sahun-Roncero M, Rubio-Ruiz B, Saladino G, Conejo-Garcia A, Espinosa A, Velazquez-Campoy A, Gervasio FL, Entrena A, Hurtado-Guerrero R. The Mechanism of Allosteric Coupling in Choline Kinase alpha1 Revealed by the Action of a Rationally Designed Inhibitor. Angew Chem Int Ed Engl. 2013 Feb 25. doi: 10.1002/anie.201209660. PMID:23441033 doi:http://dx.doi.org/10.1002/anie.201209660
