3zpc
From Proteopedia
Acinetobacter baumannii RibD, form 1
Structural highlights
FunctionD0CB74_ACIB2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[ARBA:ARBA00002151][PIRNR:PIRNR006769] Publication Abstract from PubMedThe bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 A resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain. Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.,Dawson A, Trumper P, Chrysostomou G, Hunter WN Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi:, 10.1107/S174430911301292X. Epub 2013 May 23. PMID:23722836[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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