4c5x

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4c5x, resolution 1.30Å ()
Ligands:
Non-Standard Residues:
Related: 4c63, 4c64


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethylcystosine Modification

Publication Abstract from PubMed

Transcription factor binding and high resolution crystallographic studies (1.3 A) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Structural insights into how 5-hydroxymethylation influences transcription factor binding., Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ, Chem Commun (Camb). 2013 Nov 29. PMID:24287551

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

4c5x is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb). 2013 Nov 29. PMID:24287551 doi:http://dx.doi.org/10.1039/c3cc48151d

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