4cfg
From Proteopedia
Jump to: navigation, search
proteopedia linkproteopedia linkStructure of the TRIM25 coiled-coil
Structural highlights
Function[TRI25_HUMAN] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.[1] [2] [3] See AlsoReferences
|
Retrieved from "http://proteopedia.org/wiki/index.php/4cfg"