|4doh, resolution 2.80Å ()|
|Gene:||IL20, ZCYTO10, UNQ852/PRO1801 (Homo sapiens), IL20RB, DIRS1, UNQ557/PRO1114 (Homo sapiens), IL20RA, UNQ681/PRO1315 (Homo sapiens)|
IL20/IL201/IL20R2 Ternary Complex
Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines IL-19 and IL-24, designated IL-20 subfamily cytokines (IL-20SFCs), induce cellular responses through an IL-20R1/IL-20R2 (type I) receptor heterodimer, whereas IL-20 and IL-24 also signal through the IL-22R1/IL-20R2 (type II) receptor complex. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands. The structure also defines how the receptor-cytokine interfaces are affinity tuned to allow distinct signaling through a receptor complex shared by three different ligands. Our results provide unique insights into the complexity of IL-20SFC signaling that may be critical in the design of mechanistic-based inhibitors of IL-20SFC-mediated inflammatory disease.
Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines., Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR, Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. Epub 2012 Jul 16. PMID:22802649
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
[IL20_HUMAN] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.