4eub

Structural highlights

Function

SCACT_ACEAC Utilizes succinyl-CoA to convert toxic acetate to acetyl-CoA and succinate. Required for growth on acetic acid and for resistance to high levels of acetic acid. Has also low activity with acetoacetate as substrate.^{[1] [2] [3]} [REFERENCE:3]

References

1. ↑ Mullins EA, Francois JA, Kappock TJ. A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J Bacteriol. 2008 Jul;190(14):4933-40. Epub 2008 May 23. PMID:18502856 doi:10.1128/JB.00405-08
2. ↑ Mullins EA, Kappock TJ. Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. Biochemistry. 2012 Oct 2. PMID:23030530 doi:10.1021/bi300957f
3. ↑ Mullins EA, Francois JA, Kappock TJ. A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J Bacteriol. 2008 Jul;190(14):4933-40. Epub 2008 May 23. PMID:18502856 doi:10.1128/JB.00405-08